Macular edema occurs when blood vessels in the retina begin to leak into the macula, the part of the eye responsible for detailed central vision. When this occurs in a patient with diabetes, it is referred to as diabetic macular edema or DME and is the major cause of vision loss in people with diabetic retinopathy. The lifetime risk for diabetics to develop DME is about 10%.
These leaks cause the macula to thicken and swell, progressively distorting acute vision. While the swelling may not lead to blindness, the effect can cause a severe loss in central vision. DME is classified into two types; focal and diffuse. Focal macular edema is caused by vascular abnormalities, primarily microaneurysms, which tend to leak fluid whereas diffuse macular edema is caused by dilated capillaries in the retina.